ACUTE TOXICITY ESTIMATION OF MULTICOMPONENT PLANT PROTECTION PRODUCTS USING CALCULATIONS, IN SILICO AND IN VIVO METHODS. PERSPECTIVES FOR UPDATING APPROACHES TO CLASSIFICATION AND RISK ASSESSMENT
Aim of study is to assess different alternative approaches to acute toxicity assessment of PPP, including calculation based on the assumption of additivity and in silico methods.Acute toxicity of eight PPP, containing from 2 to 5 active ingredients (AI) pesticides and number of co-formulants was assessed.In vivo studies of acute toxicity were condu